Double transgenic mice with type 1 diabetes mellitus develop somatic, metabolic and vascular disorders.
Identifieur interne : 003B48 ( Main/Exploration ); précédent : 003B47; suivant : 003B49Double transgenic mice with type 1 diabetes mellitus develop somatic, metabolic and vascular disorders.
Auteurs : D L Radu [Roumanie] ; Adriana Georgescu ; Crina Stavaru ; Alina Carale ; Doina PopovSource :
- Journal of cellular and molecular medicine [ 1582-1838 ]
Descripteurs français
- KwdFr :
- Animaux, Artère rénale (anatomopathologie), Artère rénale (physiopathologie), Artère rénale (ultrastructure), Contraction musculaire, Diabète de type 1 (), Diabète de type 1 (anatomopathologie), Diabète de type 1 (métabolisme), Endothélium vasculaire (anatomopathologie), Endothélium vasculaire (physiopathologie), Endothélium vasculaire (ultrastructure), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycosurie (urine), Glycosurie (étiologie), Glycémie (analyse), Homéostasie, Hyperglycémie (métabolisme), Hyperglycémie (étiologie), Insuline (sang), Membrane érythrocytaire (métabolisme), Microscopie électronique à transmission, Muscles lisses vasculaires (anatomopathologie), Muscles lisses vasculaires (physiopathologie), Muscles lisses vasculaires (ultrastructure), Osmose, Poids du corps, Souris, Souris de lignée BALB C, Souris transgéniques, Stress oxydatif.
- MESH :
- analyse : Glycémie.
- anatomopathologie : Artère rénale, Diabète de type 1, Endothélium vasculaire, Muscles lisses vasculaires.
- génétique : Glycoprotéine hémagglutinine du virus influenza.
- métabolisme : Diabète de type 1, Hyperglycémie, Membrane érythrocytaire.
- physiopathologie : Artère rénale, Endothélium vasculaire, Muscles lisses vasculaires.
- sang : Insuline.
- étiologie : Artère rénale, Endothélium vasculaire, Glycosurie, Hyperglycémie, Muscles lisses vasculaires.
- Animaux, Contraction musculaire, Diabète de type 1, Homéostasie, Microscopie électronique à transmission, Osmose, Poids du corps, Souris, Souris de lignée BALB C, Souris transgéniques, Stress oxydatif.
English descriptors
- KwdEn :
- Animals, Blood Glucose (analysis), Body Weight, Diabetes Mellitus, Type 1 (complications), Diabetes Mellitus, Type 1 (metabolism), Diabetes Mellitus, Type 1 (pathology), Endothelium, Vascular (pathology), Endothelium, Vascular (physiopathology), Endothelium, Vascular (ultrastructure), Erythrocyte Membrane (metabolism), Glycosuria (etiology), Glycosuria (urine), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Homeostasis, Hyperglycemia (etiology), Hyperglycemia (metabolism), Insulin (blood), Mice, Mice, Inbred BALB C, Mice, Transgenic, Microscopy, Electron, Transmission, Muscle Contraction, Muscle, Smooth, Vascular (pathology), Muscle, Smooth, Vascular (physiopathology), Muscle, Smooth, Vascular (ultrastructure), Osmosis, Oxidative Stress, Renal Artery (pathology), Renal Artery (physiopathology), Renal Artery (ultrastructure).
- MESH :
- chemical , analysis : Blood Glucose.
- chemical , blood : Insulin.
- complications : Diabetes Mellitus, Type 1.
- etiology : Glycosuria, Hyperglycemia.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- metabolism : Diabetes Mellitus, Type 1, Erythrocyte Membrane, Hyperglycemia.
- pathology : Diabetes Mellitus, Type 1, Endothelium, Vascular, Muscle, Smooth, Vascular, Renal Artery.
- physiopathology : Endothelium, Vascular, Muscle, Smooth, Vascular, Renal Artery.
- ultrastructure : Endothelium, Vascular, Muscle, Smooth, Vascular, Renal Artery.
- urine : Glycosuria.
- Animals, Body Weight, Homeostasis, Mice, Mice, Inbred BALB C, Mice, Transgenic, Microscopy, Electron, Transmission, Muscle Contraction, Osmosis, Oxidative Stress.
Abstract
The double transgenic mice (dTg) were obtained by mating: (i) transgenic mice expressing the hemagglutinin of influenza virus under the insulin promoter with (ii) transgenic mice expressing specific T lymphocytes with receptor for the immunodominant epitope of the same virus. In this study we show that dTg mice developed type 1 diabetes mellitus associated with hyperglycemia, low level of plasma insulin, glucosuria, weight loss and approximately 90% mortality (at 3 months biological age). The membrane of red blood cells was more sensitive to osmotic shock in diabetic mice, compared to non-diabetic mice, assessing systemic oxidative stress. Both vasoconstriction and vasorelaxation of the renal arteries decreased significantly in diabetic mice (compared to the control group of non-diabetic mice) related to the phenotypic change of endothelium and smooth muscle cells within the artery wall. This animal model, may be used in developing various strategies to study pancreatic beta-cell function, as well as for a better metabolic control conducting to a reduced risk of vascular complications.
DOI: 10.1111/j.1582-4934.2004.tb00324.x
PubMed: 15491510
Affiliations:
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uniqKey="Stavaru C" first="Crina" last="Stavaru">Crina Stavaru</name></author><author><name sortKey="Carale, Alina" sort="Carale, Alina" uniqKey="Carale A" first="Alina" last="Carale">Alina Carale</name></author><author><name sortKey="Popov, Doina" sort="Popov, Doina" uniqKey="Popov D" first="Doina" last="Popov">Doina Popov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2004 Jul-Sep</MedlineDate></PubDate></date><idno type="RBID">pubmed:15491510</idno><idno type="pmid">15491510</idno><idno type="doi">10.1111/j.1582-4934.2004.tb00324.x</idno><idno type="wicri:Area/PubMed/Corpus">000917</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000917</idno><idno type="wicri:Area/PubMed/Curation">000914</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000914</idno><idno type="wicri:Area/PubMed/Checkpoint">000B08</idno><idno 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xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Immunology, National Institute of Research and Development for Microbiology and Immunology Cantacuzino, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Georgescu, Adriana" sort="Georgescu, Adriana" uniqKey="Georgescu A" first="Adriana" last="Georgescu">Adriana Georgescu</name></author><author><name sortKey="Stavaru, Crina" sort="Stavaru, Crina" uniqKey="Stavaru C" first="Crina" last="Stavaru">Crina Stavaru</name></author><author><name sortKey="Carale, Alina" sort="Carale, Alina" uniqKey="Carale A" first="Alina" last="Carale">Alina Carale</name></author><author><name sortKey="Popov, Doina" sort="Popov, Doina" uniqKey="Popov D" first="Doina" last="Popov">Doina Popov</name></author></analytic><series><title level="j">Journal of cellular and molecular medicine</title><idno type="ISSN">1582-1838</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood Glucose (analysis)</term><term>Body Weight</term><term>Diabetes Mellitus, Type 1 (complications)</term><term>Diabetes Mellitus, Type 1 (metabolism)</term><term>Diabetes Mellitus, Type 1 (pathology)</term><term>Endothelium, Vascular (pathology)</term><term>Endothelium, Vascular (physiopathology)</term><term>Endothelium, Vascular (ultrastructure)</term><term>Erythrocyte Membrane (metabolism)</term><term>Glycosuria (etiology)</term><term>Glycosuria (urine)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Homeostasis</term><term>Hyperglycemia (etiology)</term><term>Hyperglycemia (metabolism)</term><term>Insulin (blood)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Transgenic</term><term>Microscopy, Electron, Transmission</term><term>Muscle Contraction</term><term>Muscle, Smooth, Vascular (pathology)</term><term>Muscle, Smooth, Vascular (physiopathology)</term><term>Muscle, Smooth, Vascular (ultrastructure)</term><term>Osmosis</term><term>Oxidative Stress</term><term>Renal Artery (pathology)</term><term>Renal Artery (physiopathology)</term><term>Renal Artery (ultrastructure)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Artère rénale (anatomopathologie)</term><term>Artère rénale (physiopathologie)</term><term>Artère rénale (ultrastructure)</term><term>Contraction musculaire</term><term>Diabète de type 1 ()</term><term>Diabète de type 1 (anatomopathologie)</term><term>Diabète de type 1 (métabolisme)</term><term>Endothélium vasculaire (anatomopathologie)</term><term>Endothélium vasculaire (physiopathologie)</term><term>Endothélium vasculaire (ultrastructure)</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycosurie (urine)</term><term>Glycosurie (étiologie)</term><term>Glycémie (analyse)</term><term>Homéostasie</term><term>Hyperglycémie (métabolisme)</term><term>Hyperglycémie (étiologie)</term><term>Insuline (sang)</term><term>Membrane érythrocytaire (métabolisme)</term><term>Microscopie électronique à transmission</term><term>Muscles lisses vasculaires (anatomopathologie)</term><term>Muscles lisses vasculaires (physiopathologie)</term><term>Muscles lisses vasculaires (ultrastructure)</term><term>Osmose</term><term>Poids du corps</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris transgéniques</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Glycémie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Artère rénale</term><term>Diabète de type 1</term><term>Endothélium vasculaire</term><term>Muscles lisses vasculaires</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Glycosuria</term><term>Hyperglycemia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Diabetes Mellitus, Type 1</term><term>Erythrocyte Membrane</term><term>Hyperglycemia</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Diabète de type 1</term><term>Hyperglycémie</term><term>Membrane érythrocytaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diabetes Mellitus, Type 1</term><term>Endothelium, Vascular</term><term>Muscle, Smooth, Vascular</term><term>Renal Artery</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Artère rénale</term><term>Endothélium vasculaire</term><term>Muscles lisses vasculaires</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Endothelium, Vascular</term><term>Muscle, Smooth, Vascular</term><term>Renal Artery</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Insuline</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Endothelium, Vascular</term><term>Muscle, Smooth, Vascular</term><term>Renal Artery</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Glycosuria</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Artère rénale</term><term>Endothélium vasculaire</term><term>Glycosurie</term><term>Hyperglycémie</term><term>Muscles lisses vasculaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Homeostasis</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Transgenic</term><term>Microscopy, Electron, Transmission</term><term>Muscle Contraction</term><term>Osmosis</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Contraction musculaire</term><term>Diabète de type 1</term><term>Homéostasie</term><term>Microscopie électronique à transmission</term><term>Osmose</term><term>Poids du corps</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris transgéniques</term><term>Stress oxydatif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The double transgenic mice (dTg) were obtained by mating: (i) transgenic mice expressing the hemagglutinin of influenza virus under the insulin promoter with (ii) transgenic mice expressing specific T lymphocytes with receptor for the immunodominant epitope of the same virus. In this study we show that dTg mice developed type 1 diabetes mellitus associated with hyperglycemia, low level of plasma insulin, glucosuria, weight loss and approximately 90% mortality (at 3 months biological age). The membrane of red blood cells was more sensitive to osmotic shock in diabetic mice, compared to non-diabetic mice, assessing systemic oxidative stress. Both vasoconstriction and vasorelaxation of the renal arteries decreased significantly in diabetic mice (compared to the control group of non-diabetic mice) related to the phenotypic change of endothelium and smooth muscle cells within the artery wall. This animal model, may be used in developing various strategies to study pancreatic beta-cell function, as well as for a better metabolic control conducting to a reduced risk of vascular complications.</div></front></TEI><affiliations><list><country><li>Roumanie</li></country></list><tree><noCountry><name sortKey="Carale, Alina" sort="Carale, Alina" uniqKey="Carale A" first="Alina" last="Carale">Alina Carale</name><name sortKey="Georgescu, Adriana" sort="Georgescu, Adriana" uniqKey="Georgescu A" first="Adriana" last="Georgescu">Adriana Georgescu</name><name sortKey="Popov, Doina" sort="Popov, Doina" uniqKey="Popov D" first="Doina" last="Popov">Doina Popov</name><name sortKey="Stavaru, Crina" sort="Stavaru, Crina" uniqKey="Stavaru C" first="Crina" last="Stavaru">Crina Stavaru</name></noCountry><country name="Roumanie"><noRegion><name sortKey="Radu, D L" sort="Radu, D L" uniqKey="Radu D" first="D L" last="Radu">D L Radu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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